list biological laboratories公司是世界的科研毒素試劑供應(yīng)商，其毒素包括霍亂病毒，蛇毒，百日咳毒素等各類毒素,我公司常年低價(jià)供應(yīng),貨期快.有意者請(qǐng). 百日咳毒素長(zhǎng)期現(xiàn)貨供應(yīng)，貨號(hào)181及180。
list biological 758A
一種主要的醫(yī)院病原體，艱難梭菌（Clostridium difficile）引起抗生素相關(guān)性結(jié)腸炎和腸道炎癥性疾病，一起稱為CDI。
C艱難梭菌毒素如何引起腹瀉？ 通過釋放兩種大蛋白腸毒素，艱難梭菌毒素A（TcdA）和艱難梭菌毒素B（TcdB），艱難梭菌介導(dǎo)炎性腹瀉并損害腸??上皮細(xì)胞。施用于培養(yǎng)細(xì)胞時(shí)的毒素都會(huì)破壞細(xì)胞骨架并引發(fā)細(xì)胞凋亡依賴性細(xì)胞凋亡，盡管艱難梭菌毒素B的效力比艱難梭菌多很多倍。毒素A.兩種毒素還激活腸上皮細(xì)胞和免疫細(xì)胞以產(chǎn)生細(xì)胞因子和趨化因子，可能導(dǎo)致與嚴(yán)重CDI相關(guān)的并發(fā)癥。TcdA和TcdB的細(xì)胞內(nèi)靶標(biāo)是RhoGTP酶，其調(diào)節(jié)許多宿主細(xì)胞過程，包括建立上皮屏障和免疫細(xì)胞的遷移和信號(hào)傳導(dǎo)。當(dāng)Rho蛋白被艱難梭菌毒素A或B 糖基化時(shí)，信號(hào)被破壞，導(dǎo)致CDI的腸損傷和炎癥特征。
List Labs C. Difficile Toxins參與了診斷的研究和開發(fā)。
抗艱難梭菌二元毒素B亞基（雞lgY）
產(chǎn)品＃和尺寸
＃758A（0.1毫克） - 320.00美元
艱難梭菌是引起抗生素相關(guān)性腹瀉和假膜性大腸桿菌的病原體。
1，2它產(chǎn)生兩種主要的外毒素(毒素A和毒素B)。
大型梭狀細(xì)胞毒素科。一些艱難梭菌還產(chǎn)生一種二價(jià)ADP-核糖化毒素(CDT)，這種毒素可以修飾actin3 CDT二元毒素在疾病誘導(dǎo)中的致病作用 艱難梭菌的ED尚不清楚，但從結(jié)腸炎患者中分離出的約10%的菌株含有CDT二元毒素基因。
4，5艱難梭菌A和B為高分子量葡糖基轉(zhuǎn)運(yùn)體。 抑制GTPases Rho家族成員的rase。毒素A被稱為腸毒素，分子量為300 kDa，等電點(diǎn)為5.3。毒素B，被稱為細(xì)胞毒素， 分子量為270 kDa，pl為4.1。毒素A和毒素B通過蘇氨酸殘基的葡萄糖化使Rho、RAC和Cdc 42等小GTPase失活。6，7，8抑制這些GTPase S導(dǎo)致信號(hào)轉(zhuǎn)導(dǎo)級(jí)聯(lián)的關(guān)閉，導(dǎo)致細(xì)胞骨架的解聚，某些應(yīng)激激活蛋白激酶的基因轉(zhuǎn)錄，磷脂合成的下降。
Ylinositol 4，5二磷酸甚至可能導(dǎo)致細(xì)胞極化的喪失9細(xì)胞骨架結(jié)構(gòu)的喪失導(dǎo)致細(xì)胞的四舍五入，這種結(jié)構(gòu)的喪失可能是宿主對(duì)C的反應(yīng)的原因。 艱難。毒素A和B所針對(duì)的GTP酶與許多細(xì)胞反應(yīng)有關(guān)，但這些毒素具有不同的生理效應(yīng)。這兩種毒素都會(huì)刺激皮膚，增加維生素A。 [10]只有毒素A在上皮細(xì)胞表面有一個(gè)結(jié)合位點(diǎn)，即碳水化合物11，這可能與兔回腸的劇烈反應(yīng)有關(guān)。23，
13毒素B是一種p型毒素。 組織培養(yǎng)中哺乳動(dòng)物細(xì)胞的細(xì)胞毒素14，
15毒素B在細(xì)胞四舍五入中的毒性至少是毒素A的1000倍。通過抑制信號(hào)轉(zhuǎn)導(dǎo)級(jí)聯(lián)，毒素A 毒素B可以阻斷下游的反應(yīng)。毒素A可誘導(dǎo)白介素8.
16毒素B可能阻斷5-羥色胺的釋放，
17以及刺激磷脂的產(chǎn)生 ESC和D.
18，19由于具有影響細(xì)胞骨架解聚的能力，毒素B被證明能抑制雙相肌肉收縮。
20艱難梭菌毒素A和B有63%的同源性。 每種毒素的C-末端第三位都是由被稱為梭狀重復(fù)寡肽(作物)的高度序列組成。 Y抗原。其余的N端三分之二的毒素A和B在序列同源性方面不太相似，但每種蛋白質(zhì)的這一部分都含有葡萄糖。
22，23 CDT二元毒素是ADP-核糖轉(zhuǎn)移酶家族(ADPRT)的成員。3 CDT二元毒素與C.肉毒桿菌C2毒素同屬于AB二元毒素亞家族。 產(chǎn)氣莢膜的毒素。
24該二元毒素由兩個(gè)獨(dú)立產(chǎn)生的組分組成，即酶組分A亞基CdtA(48 KD)和結(jié)合和易位復(fù)合物。 Nent B亞基CdtB(94 KD)介導(dǎo)CdtA細(xì)胞的進(jìn)入。
25 cdt二元毒素引起肌動(dòng)蛋白細(xì)胞骨架的解聚和微管基膜突起的形成。
[26]CDT二價(jià)毒素B亞基cdtB是cdtA進(jìn)入TH的必需物質(zhì)。26 CDT二進(jìn)毒素cdtB亞基cdtB參與了高致病性艱難梭菌的粘附和定植。
27 CdtB組分必須通過切割激活，然后在細(xì)胞表面形成七肽，并與特定的細(xì)胞表面受體結(jié)合。細(xì)胞表面受體已被識(shí)別 28隨后，CdtA與CdtB結(jié)合，通過受體介導(dǎo)的內(nèi)吞作用進(jìn)入細(xì)胞。cdtA的N端與INTERA有關(guān)。 在cdtB作用下，C端含有酶活性。29根據(jù)lota毒素的活性，預(yù)測(cè)cdp-核糖單聚體G-actin在arg 17上將不可逆轉(zhuǎn)。 7殘留。這種ADP-核糖基化將阻止G-肌動(dòng)蛋白與F-肌動(dòng)蛋白的聚合，破壞F-actin：G-actin的平衡，從而導(dǎo)致細(xì)胞的四舍五入和細(xì)胞死亡。
產(chǎn)品僅用于研究目的，不用于人類或診斷劑。
貨號(hào) | 品名 | 規(guī)格 | 價(jià)格 |
list104 | Cholera Toxin B Subunit (Choleragenoid) in low salt1 | 0.5mg | 4930 |
list106 | Cholera Toxin B Subunit Fluorescein Isothiocyanate Conjugate (BFITC) | 0.2mg | 9775 |
list112 | Cholera Toxin B Subunit Biotin | 0.2mg | 9775 |
list122 | Enterotoxin Type B from Staphylococcus aureus1,3 | 0.5mg | 7225 |
list123 | Enterotoxin Type B Toxoid from Staphylococcus aureus 1,3 | 0.25mg | 8075 |
list139 | Botulinum Neurotoxin Type B Toxoid | 10µg | 6800 |
list150 | Diphtheria Toxin, unnicked from Corynebacterium diphtheriae | 1mg | 11050 |
list151 | Diphtheria Toxoid, from Corynebacterium diphtheriae | 0.5mg | 10625 |
list153 | Toxin A Toxoid from Clostridium difficile | 100µg | 11900 |
list156 | Pasteurella Multocida Toxin | 50µg | 8075 |
list160 | Exotoxin A from Pseudomonas aeruginosa | 1mg | 4420 |
list161 | Shiga Toxin 1 from Escherichia coli1,4,8 | 10µg | 11900 |
list162 | Shiga Toxin 2 from Escherichia coli1,4,8 | 10µg | 11050 |
list174 | Anthrax Protective Antigen, Activated (PA 63) from Bacillus anthracis | 0.5mg | 9350 |
list175 | Anthrax PA 63 - Fluorescein Isothiocyanate Conjugate (PAFITC) | 50µg | 7225 |
list180 | Pertussis Toxin Islet-Activating Protein Lyophilized in buffer | 50µg | 5525 |
list181 | Pertussis Toxin Islet Activating Protein Lyophilized (Salt-Free) | 50µg | 5525 |
list184 | Pertussis Toxin Mutant | 50µg | 5525 |
list186 | FIMBRIAE 2/3 from B. pertussis | 50µg | 5950 |
list187 | Pertactin from Bordetella pertussus (69 kDa Protein) | 50µg | 4590 |
list193 | Tetanus Toxin C Fragment | 10µg | 9350 |
list201 | LPS from Escherichia coli O111:B4 | 5mg | 3230 |
list206 | LPS, Escherichia coli 0157:H7 | 10.0mg | 4760 |
list225 | LPS from Salmonella typhimurium | 5mg | 2890 |
list301 | LPS from Escherichia coli J5 (Rc) | 5mg | 2890 |
list302 | LPS from Escherichia coli K12, D31m4 (Re) | 5mg | 2890 |
list304 | LPS from Salmonella minnesota R595 (Re) | 5mg | 2890 |
list314 | LPS from Escherichia coli K12 strain LCD25 | 1mg | 2890 |
list400 | HPT™ LPS, highly purified from Bordetella Pertussis 165 | 1mg | 5100 |
list401 | Lipid A monophosphoryl from Salmonella minnesota R595 | 1mg | 3400 |
list421 | Ultra Pure LPS from Escherichia coli O111:B4 | 1mg | 3570 |
list423 | Ultra Pure LPS from Escherichia coli O55:B5 | 1mg | 3570 |
list433 | LISTÔ HPTÔ, LPS, highly purified Escherichia coli O113 LPS | 1mg | 4080 |
list434 | Ultra Pure LPS from Salmonella minnesota R595 (Re) | 1mg | 3400 |
list520 | SNAPtide® Peptide Substrate (o-Abz/Dnp) (U.S. Patent #6,504,006) | 200nmoles | 9775 |
list521 | SNAPtide® Peptide Substrate (FITC/DABCYL) (U.S. Patent #6,504,006) | 200nmoles | 8500 |
list523 | SNAPtideÒ Peptide Substrate flP6 (DABCYL/5-IAF), U.S. Patent Pending #61/252,675 | 200nmoles | 8500 |
list525 | Control Peptide for SNAPtideÒ #520 | 200nmoles | 8500 |
list526 | Control Peptide for SNAPtide® #521 | 200nmoles | 8500 |
list528 | Unquenched Calibration Peptide for SNAPtide® 521 | 50nmoles | 2890 |
list529 | Unquenched Calibration Peptide for SNAPtide® 520 | 50nmoles | 2890 |
list530 | MAPKKide® Peptide Substrate (o-Abz/Dnp) | 200nmoles | 5100 |
list531 | MAPKKide® Peptide Substrate (DABCYL/FITC) | 200nmoles | 5100 |
list532 | MAPKKide® Plus (AMC) Specific Substrate for Anthrax Lethal Factor | 100nmoles | 4250 |
list539 | Unquenched Calibration Peptide for MAPKKideÒ 530 | 50nmoles | 2890 |
list540 | VAMPtide® Peptide Substrate (o-Abz/Dnp) | 200nmoles | 8500 |
list541 | VAMPtide® Peptide Substrate (FITC/DABCYL) | 200nmoles | 8500 |
list542 | VAMPtide® Peptide Substrate (PL 150, Pya/Nop) | 200nmoles | 8500 |
list549 | Calibration Fluorophore for VAMPtideÒ 540 | 100nmoles | 2890 |
list550 | SNAP Etide® Peptide Substrate (o-Abz/Dnp) | 100nmoles | 6800 |
list560 | SYNTAXtideÒ Peptide Substrate (o-Abz/Dnp) for C. botulinum Type C | 200nmoles | 8500 |
list703 | Anti-Cholera Toxin B Subunit (Goat) | 0.1ml | 3060 |
list752 | Anti-Toxin A from Clostridium difficile (Goat) | 0.5ml | 3230 |
list760 | Anti-Exotoxin A (Goat) | 0.5ml | 3400 |
list781 | Anti-Protective Antigen from Bacillus anthracis (Goat) affinity purified, Liquid6,7 | 0.1mg | 7055 |
list100B | Cholera Toxin (Azide Free)1 | 1mg | 3400 |
list101B | Cholera Toxin1 | 1mg | 3400 |
list101C | Cholera Toxin1 | 2mg | 5355 |
list116L | Alpha Toxin from C. septicum4,6,7 | 50µg | 4930 |
list126A | Epsilon Toxin from C. perfringens1,4,8 | 0.1mg | 5950 |
list128A | Botulinum Neurotoxin Type A Complex from Clostridium botulinum1,3 | 10µg | 2890 |
list128C | Botulinum Neurotoxin Type A Complex from Clostridium botulinum1,3 | 100µg | 5440 |
list130A | Botulinum Neurotoxin Type A from Clostridium botulinum1,3 | 10µg | 5440 |
list130B | Botulinum Neurotoxin Type A from Clostridium botulinum1,3 | 100µg | 13600 |
list133L | Botulinum Neurotoxin Type A Toxoid, Liquid6,7 | 10µg | 5440 |
list136A | Botulinum Neurotoxin Type B. from Clostridium botulinum 1,3 | 10µg | 5100 |
list136B | Botulinum Neurotoxin Type B, from Clostridium botulinum1,3 | 100µg | 17000 |
list138A | Botulinum Neurotoxin Type B Complex, Nicked, from Clostridium botulinum1,3 | 10µg | 2890 |
list138B | Botulinum Neurotoxin Type B Complex, Nicked, from Clostridium botulinum1,3 | 100µg | 7225 |
list140A | Botulinum Neurotoxin Type E, Nicked, Complex from Clostridium botulinum1,3 | 10µg | 2890 |
list140B | Botulinum Neurotoxin Type E, Nicked, Complex from Clostridium botulinum1,3 | 100µg | 8925 |
list141A | Botulinum Neurotoxin Type E, Nicked, from Clostridium botulinum1,3 | 10µg | 8075 |
list146A | Botulinum Neurotoxin Type D, Nicked, Recombinant from Clostridium botulinum1,3 | 10µg | 5355 |
list149A | Diphtheria Toxin CRM Mutant | 0.25 mg | 8500 |
list152C | Toxin A from Clostridium difficile | 100µg | 9010 |
list154A | Toxin B Toxoid from Clostridium difficile | 20µg | 2890 |
list15 | Toxin B from Clostridium difficile | 2µg | 2890 |
list155B | Toxin B from Clostridium difficile | 20µg | 8500 |
list155C | Toxin B from Clostridium difficile | 200µg | 15300 |
list155L | Toxin B from Clostridium difficile, Liquid6,7 | 50µg | 9860 |
list157A | Binary Toxin from Clostridium difficile, A Subunit | 20µg | 5950 |
list158A | Binary Toxin from Clostridium difficile, B Subunit | 40µg | 5950 |
list159A | Glutamate Dehydrogenase (GDH) from Clostridium difficile6,7 | 0.1mg | 4930 |
list169A | Anthrax Lethal Factor (LF-A) , Recombinant from Bacillus anthracis Native Sequence | 0.1mg | 3060 |
list169B | Anthrax Lethal Factor (LF-A),Recombinant from Bacillus anthracis Native Sequence | 1mg | 12750 |
list169L | Anthrax Lethal Factor (LF-A),Recomb.from Bacillus anthracis 5,7 | 0.2 mg | 5950 |
list171E | Anthrax Protective Antigen (PA), Recombinant from Bacillus anthracis | 0.5mg | 8755 |
list172B | Anthrax Lethal Factor (LF), Recombinant from Bacillus anthracis | 1mg | 12750 |
list172C | Anthrax Lethal Factor (LF), Recombinant from Bacillus anthracis | 10mg | 39525 |
list172L | Lethal Factor, Recomb from Bacillus anthracis, froz liq 5,7 | 1.0 mg | 12750 |
list173B | Anthrax Edema Factor (EF), Recombinant Mutant S447N from Bacillus anthracis | 0.5mg | 16150 |
list176A | Anthrax Lethal Factor (LF), Recombinant, Mutant E687C from Bacillus anthracis | 0.1mg | 5100 |
list176B | Anthrax Lethal Factor (LF), Recombinant, Mutant E687C from Bacillus anthracis | 1mg | 16150 |
list177A | Anthrax Protective Antigen Fragment (PA 20) from Bacillus anthracis | 50µg | 5950 |
list177B | Anthrax Protective Antigen Fragment (PA 20) from Bacillus anthracis | 0.25mg | 11050 |
list178A | Anthrax Edema Factor (EF), Recombinant from Bacillus anthracis | 0.1mg | 2890 |
list179A | Pertussis Toxin Islet Activating Protein (in glycerol)6,7 | 50µg | 4845 |
list188L | Adenylate Cyclase Toxin from B. pertussis, Recombinant, Frozen Liquid5,7 | 50µg | 5270 |
list190A | Tetanus Toxin2 | 25µg | 2890 |
list190B | Tetanus Toxin2 | 100µg | 9350 |
list191A | Tetanus Toxoid | 25µg | 4675 |
list191B | Tetanus Toxoid | 100µg | 13600 |
list196A | C-fragment, FITC Conjugate | 10µg | 6800 |
list203A | LPS, Escherichia coli O55:B5 | 2.5 mg | 3060 |
list500A | SNAP-25 Recomb Protein Substrate for C. botulinum Type A and E Neurotoxin | 100µg | 5525 |
list510A | GST Synaptobrevin-2 Protein Recomb. Protein Substrate for C. botulinum Type B,D and F | 100µg | 5950 |
list610A | Botulinum Neurotoxin Type A Light Chain, Recombinant1 | 10µg | 4760 |
list611A | Botulinum Neurotoxin Type A Light Chain, GST Fusion, Recombinant1 | 15µg | 4760 |
list612A | Botulinum Neurotoxin Type A Heavy Chain, Recombinant, Binding Domain1 | 50µg | 4760 |
list613A | Botulinum Neurotoxin Type A Heavy Chain, Recombinant, Binding Domain, GST Fusion1 | 50µg | 4760 |
list620A | Botulinum Neurotoxin Type B Light Chain, Recombinant1 | 10µg | 8500 |
list622A | Botulinum Neurotoxin Type B Heavy Chain, Recombinant, Binding Domain1 | 50µg | 4760 |
list623A | Botulinum Neurotoxin Type B Heavy Chain, Recombinant, Binding Domain, GST Fusion1 | 50µg | 4760 |
list62 | Botulinum Neurotoxin Type C Light Chain, Recombinant1 | 10µg | 8500 |
list630A | Botulinum Neurotoxin Type D Light Chain, Recombinant1 | 10µg | 5695 |
list650A | Tetanus Toxin Light Chain, Recombinant | 10µg | 3825 |
list690B | Receptor for C. botulinum Type A Neurotoxin GST-SV2c luminal domain | 100nmoles | 6800 |
list730A | Anti-Botulinum Neurotoxin, Type A (Chicken lgY), Liquid6,7 | 0.1mg | 5610 |
list731L | Anti-Botulinum Neurotoxin, Type A (Mouse lgG monoclonal F1-40), Liquid6,7 | 0.1mg | 5950 |
list736A | Anti-Botulinum Type B (Chicken lgY), Liquid6,7 | 0.1mg | 5950 |
list753A | Anti-Clostridium difficile Toxin A (Chicken lgY), Liquid6,7 | 0.1mg | 5780 |
list754A | Anti-Clostridium difficile Toxin B (Chicken lgY), Liquid6,7 | 0.1mg | 5780 |
list756A | Anti-Clostridium difficile Glutamate Dehydrogenase, lgY, Liquid6,7 | 0.1mg | 5780 |
list757A | Anti-Clostridium difficile Binary Toxin A subunit (Chicken lgY), Liquid6,7 | 0.1mg | 5780 |
list758A | Anti-Clostridium difficile Binary Toxin B subunit (Chicken lgY), Liquid6,7 | 0.1mg | 5780 |
list759A | Biotinylated Anti-Clostridium difficile Binary Toxin B subunit (Chicken lgY), Liquid6,7 | 0.1mg | 5780 |
list761L | Anti-Shiga Toxin 1 (Rabbit), lgG, Liquid6,7 | 0.5mg | 3400 |
list765L | Anti-Shiga Toxin 2 (Rabbit), IgG, Liquid6,7 | 0.5mg | 2890 |
list766L | Anti-Shiga Toxin, Camelid Antibody, VHH, Liquid6,7 | 0.5mg/ml | 5950 |
list768L | Biotinylated Anti-Lethal Factor from B. anthracis, IgY, Liquid6,7 | 0.1mg | 5950 |
list769B | Anti-Lethal Factor from Bacillus anthracis (Chicken lgY), Liquid6,7 | 0.2mg | 8500 |
list771B | Anti-Protective Antigen from Bacillus anthracis (Goat) | 1mg | 2890 |
list772B | Anti-Lethal Factor from Bacillus anthracis (Goat) | 1.0 mg | 2890 |
list773L | Anti-Edema Factor from Bacillus anthracis (Goat), Liquid6,7 | 1mg | 2890 |
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